 |
Center for Nonlinear Studies |
If life were designed in a virtual world, DNA replication, transcription and protein translation would be simple. We just need to write down the rule that A pairs with T, C with G, and another rule that three of the letters encode for amino-acids. However, DNA is a physical entity, and as such, sequence-dependent mechanical properties of DNA likely played a role during the evolution of present-day genomes. In order to understand how DNA sequence determines its mechanics, we developed methods to measure, experimentally, DNA mechanics at the genome scale. I will discuss some of our findings on the mechanical code of the genome and epigenome. In the second part of the talk, I will discuss a new technology, very fast CRSIPR, to create a precision DNA damage at high spatiotemporal by combining photoactivation and CRISPR systems.
Host: Angel Garcia