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Thursday, September 07, 2023
1:00 PM - 2:00 PM
CNLS Conference Room (TA-3, Bldg 1690)

Seminar

Using deep mutational scanning to interpret and forecast viral evolution

Jesse Bloom
Professor Fred Hutchinson Cancer Research Center; Investigator Howard Hughes Medical Institute

The rapid evolution of some human viruses can lead to erosion of antibody immunity, as typified by SARS-CoV-2. I will discuss how high-throughput deep mutational scanning experiments can be used to map the antigenic effects of viral mutations in the lab, and then better interpret the evolution of viruses in nature. Additionally, I will discuss how such approaches can be generalized to other viruses, including ones thought to have pandemic potential.

Host: Paul Fenimore